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Combining eQTL and SNP Annotation Data to Identify Functional Noncoding SNPs in GWAS Trait-Associated Regions.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Ramsey Stephen A, Liu Zheng, Yao Yao, Weeder Benjamin

Abstract excerpt

We describe a statistical method for prioritizing candidate causal noncoding single nucleotide polymorphisms (SNPs) in regions of the genome that are detected as trait-associated in a population-based genome-wide association study (GWAS). Our method's key step is to combine, within a naïve Bayes-like framework, three quantities for each SNP: (1) the p-value for the association test between the SNP's genotype and...

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PMID: 31849009
DOI: 10.1007/978-1-0716-0026-9_6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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