Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.

doi:10.1242/dmm.028035

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Article

Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.

Disease models & mechanisms - 1 May 2017

Lahut Suna, Gispert Suzana, Ömür Özgür, Depboylu Candan, Seidel Kay, Domínguez-Bautista Jorge Antolio, Brehm Nadine, Tireli Hülya, Hackmann Karl, Pirkevi Caroline, Leube Barbara, Ries Vincent, Reim Kerstin, Brose Nils, den Dunnen Wilfred F, Johnson Madrid, Wolf Zsuzsanna, Schindewolf Marc, Schrempf Wiebke, Reetz Kathrin, Young Peter, Vadasz David, Frangakis Achilleas S, Schröck Evelin, Steinmetz Helmuth, Jendrach Marina, Rüb Udo, Başak Ayşe Nazlı, Oertel Wolfgang, Auburger Georg

Abstract excerpt

Parkinson's disease (PD) is a frequent neurodegenerative process in old age. Accumulation and aggregation of the lipid-binding SNARE complex component α-synuclein (SNCA) underlies this vulnerability and defines stages of disease progression. Determinants of SNCA levels and mechanisms of SNCA neurotoxicity have been intensely investigated. In view of the physiological roles of SNCA in blood to modulate vesicle...

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Identifiers

PMID: 28108469
DOI: 10.1242/dmm.028035
PMCID: PMC5451169

Genes

SNCA
CPLX1
GZMH
PLTP
SPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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