Article
An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells.
Nature communications - 16 Dec 2019
Shen Shensi, Faouzi Sara, Bastide Amandine, Martineau Sylvain, Malka-Mahieu Hélène, Fu Yu, Sun Xiaoxiao, Mateus Christine, Routier Emilie, Roy Severine, Desaubry Laurent, André Fabrice, Eggermont Alexander, David Alexandre, Scoazec Jean-Yves, Vagner Stéphan, Robert Caroline
Abstract excerpt
Cancer persister cells tolerate anticancer drugs and serve as the founders of acquired resistance and cancer relapse. Here we show that a subpopulation of BRAFV600 mutant melanoma cells that tolerates exposure to BRAF and MEK inhibitors undergoes a reversible remodelling of mRNA translation that evolves in parallel with drug sensitivity. Although this process is associated with a global reduction in protein...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.