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Article

C/EBPα transcription factor is regulated by the RANK cytoplasmic 535IVVY538 motif and stimulates osteoclastogenesis more strongly than c-Fos.

The Journal of biological chemistry - 26 Jan 2018

Jules Joel, Chen Wei, Feng Xu, Li Yi-Ping

Abstract excerpt

Binding of receptor activator of NF-κB ligand (RANKL) to its receptor RANK on osteoclast (OC) precursors up-regulates c-Fos and CCAAT/enhancer-binding protein-α (C/EBPα), two critical OC transcription factors. However, the effects of c-Fos and C/EBPα on osteoclastogenesis have not been compared. Herein, we demonstrate that overexpression of c-Fos or C/EBPα in OC precursors up-regulates OC genes and initiates...

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Identifiers

PMID: 29122885
DOI: 10.1074/jbc.M116.736009
PMCID: PMC5787821

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