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Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer’s disease-related dysregulation

1 Dec 2019

Abstract excerpt

BACKGROUND: Trisomy 21 (T21) is associated with intellectual disability that ranges from mild to profound with an average intellectual quotient of around 50. Furthermore, T21 patients have a high risk of developing Alzheimer's disease (AD) early in life, characterized by the presence of senile plaques of amyloid protein and neurofibrillary tangles, leading to neuronal loss and cognitive decline. We postulate that...

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PMID: 31843015
DOI: 10.1186/s13148-019-0787-x

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