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Article

Genetic Programs Driving Oncogenic Transformation: Lessons from in Vitro Models.

International journal of molecular sciences - 12 Dec 2019

Giorgio Eros Di, Paluvai Harikrishnareddy, Picco Raffaella, Brancolini Claudio

Abstract excerpt

Cancer complexity relies on the intracellular pleiotropy of oncogenes/tumor suppressors and in the strong interplay between tumors and micro- and macro-environments. Here we followed a reductionist approach, by analyzing the transcriptional adaptations induced by three oncogenes (RAS, MYC, and HDAC4) in an isogenic transformation process. Common pathways, in place of common genes became dysregulated. From our...

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Identifiers

PMID: 31842516
DOI: 10.3390/ijms20246283
PMCID: PMC6940909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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