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Article

Potent and broad neutralization of HIV-1 subtype C by plasma antibodies targeting a quaternary epitope including residues in the V2 loop.

Journal of virology - 1 Apr 2011

Moore Penny L, Gray Elin S, Sheward Daniel, Madiga Maphuti, Ranchobe Nthabeleng, Lai Zhong, Honnen William J, Nonyane Molati, Tumba Nancy, Hermanus Tandile, Sibeko Sengeziwe, Mlisana Koleka, Abdool Karim Salim S, Williamson Carolyn, Pinter Abraham, Morris Lynn

Abstract excerpt

The targets of broadly cross-neutralizing (BCN) antibodies are of great interest in the HIV vaccine field. We have identified a subtype C HIV-1-superinfected individual, CAP256, with high-level BCN activity, and characterized the antibody specificity mediating breadth. CAP256 developed potent BCN activity peaking at 3 years postinfection, neutralizing 32 (76%) of 42 heterologous viruses, with titers of antibodies...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21270156
DOI: 10.1128/JVI.02658-10
PMCID: PMC3067856

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