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Article

Computational design of self-assembling protein nanomaterials with atomic level accuracy.

Science (New York, N.Y.) - 1 Jun 2012

King Neil P, Sheffler William, Sawaya Michael R, Vollmar Breanna S, Sumida John P, André Ingemar, Gonen Tamir, Yeates Todd O, Baker David

Abstract excerpt

We describe a general computational method for designing proteins that self-assemble to a desired symmetric architecture. Protein building blocks are docked together symmetrically to identify complementary packing arrangements, and low-energy protein-protein interfaces are then designed between the building blocks in order to drive self-assembly. We used trimeric protein building blocks to design a 24-subunit,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22654060
DOI: 10.1126/science.1219364
PMCID: PMC4138882

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