BEN-solo factors partition active chromatin to ensure proper gene activation in Drosophila.

doi:10.1038/s41467-019-13558-8

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Article

BEN-solo factors partition active chromatin to ensure proper gene activation in Drosophila.

Nature communications - 13 Dec 2019

Ueberschär Malin, Wang Huazhen, Zhang Chun, Kondo Shu, Aoki Tsutomu, Schedl Paul, Lai Eric C, Wen Jiayu, Dai Qi

Abstract excerpt

The Drosophila genome encodes three BEN-solo proteins including Insensitive (Insv), Elba1 and Elba2 that possess activities in transcriptional repression and chromatin insulation. A fourth protein-Elba3-bridges Elba1 and Elba2 to form an ELBA complex. Here, we report comprehensive investigation of these proteins in Drosophila embryos. We assess common and distinct binding sites for Insv and ELBA and their genetic...

Topics

Animals
Animals, Genetically Modified
Cell Line
Chromatin
Co-Repressor Proteins
DNA-Binding Proteins
Drosophila Proteins
Drosophila melanogaster
Embryo, Nonmammalian
Mutation
Transcription Factors
Transcriptional Activation

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Identifiers

PMID: 31836703
DOI: 10.1038/s41467-019-13558-8
PMCID: PMC6911014

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