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Article

The BEAF insulator regulates genes involved in cell polarity and neoplastic growth.

Developmental biology - 1 Sept 2012

Gurudatta B V, Ramos Edward, Corces Victor G

Abstract excerpt

Boundary Element Associated Factor-32 (BEAF-32) is an insulator protein predominantly found near gene promoters and thought to play a role in gene expression. We find that mutations in BEAF-32 are lethal, show loss of epithelial morphology in imaginal discs and cause neoplastic growth defects. To investigate the molecular mechanisms underlying this phenotype, we carried out a genome-wide analysis of BEAF-32...

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Identifiers

PMID: 22743648
DOI: 10.1016/j.ydbio.2012.06.013
PMCID: PMC3572785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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