Article
Genetic disruption of KCC cotransporters in a mouse model of thalassemia intermedia.
Blood cells, molecules & diseases - 1 Mar 2020
Shmukler Boris E, Rivera Alicia, Bhargava Parul, Nishimura Katherine, Kim Edward H, Hsu Ann, Wohlgemuth Jay G, Morton James, Snyder L Michael, De Franceschi Lucia, Rust Marco B, Hubner Christian A, Brugnara Carlo, Alper Seth L
Abstract excerpt
β-thalassemia (β-Thal) is caused by defective β-globin production leading to globin chain imbalance, aggregation of free alpha chain in developing erythroblasts, reticulocytes, and mature circulating red blood cells. The hypochromic thalassemic red cells exhibit increased cell dehydration in association with elevated K+ leak and increased K-Cl cotransport activity, each of which has been linked to globin chain...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.