Article
von Willebrand factor and factor VIII levels after desmopressin are associated with bleeding phenotype in type 1 VWD.
Blood advances - 23 Dec 2019
Atiq Ferdows, Schütte Lisette M, Looijen Agnes E M, Boender Johan, Cnossen Marjon H, Eikenboom Jeroen, de Maat Moniek P M, Kruip Marieke J H A, Leebeek Frank W G
Abstract excerpt
The bleeding phenotype of patients with type 1 von Willebrand disease (VWD) is very heterogeneous. We hypothesized that this heterogeneity may partly be explained by variability in response of von Willebrand factor (VWF) and factor VIII (FVIII) levels to stress during hemostatic challenges. We therefore investigated whether VWF and FVIII levels after administration of desmopressin, which mimic in vivo hemostatic...
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