Article
Determinants of bleeding phenotype in adult patients with moderate or severe von Willebrand disease.
Thrombosis and haemostasis - 1 Oct 2012
de Wee Eva M, Sanders Yvonne V, Mauser-Bunschoten Eveline P, van der Bom Johanna G, Degenaar-Dujardin Manon E L, Eikenboom Jeroen, de Goede-Bolder Arja, Laros-van Gorkom Britta A P, Meijer Karina, Hamulyák Karly, Nijziel Marten R, Fijnvandraat Karin, Leebeek Frank W G
Abstract excerpt
We performed a nation-wide cross-sectional study to evaluate determinants of bleeding symptoms in a large unselected cohort of adults with von Willebrand disease (VWD). VWD patients were included (n=664), based on lowest historically measured VWF:Ag and VWF:Act levels ≤30 U/dl. Menorrhagia (85%), cutaneous bleeding (77%), bleeding from minor wounds (77%) and oral-cavity bleeding (62%) occurred most frequently....
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