Article
Advances in the diagnosis and management of type 1 von Willebrand disease.
Expert review of hematology - 1 Feb 2011
Castaman Giancarlo, Rodeghiero Francesco
Abstract excerpt
Von Willebrand disease (VWD) is an autosomally inherited bleeding disorder caused by a deficiency and/or abnormality of von Willebrand factor (VWF). VWF is a multimeric adhesive protein that plays an important role in primary hemostasis by promoting platelet adhesion to the subendothelium at sites of vascular injury and platelet-platelet interactions at high-shear rate conditions. Furthermore, VWF is the carrier...
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