Article
Response to desmopressin is influenced by the genotype and phenotype in type 1 von Willebrand disease (VWD): results from the European Study MCMDM-1VWD.
Blood - 1 Apr 2008
Castaman Giancarlo, Lethagen Stefan, Federici Augusto B, Tosetto Alberto, Goodeve Anne, Budde Ulrich, Batlle Javier, Meyer Dominique, Mazurier Claudine, Fressinaud Edith, Goudemand Jenny, Eikenboom Jeroen, Schneppenheim Reinhard, Ingerslev Jorgen, Vorlova Zdena, Habart David, Holmberg Lars, Pasi John, Hill Frank, Peake Ian, Rodeghiero Francesco
Abstract excerpt
We have prospectively evaluated the biologic response to desmopressin in 77 patients with type 1 von Willebrand disease (VWD) enrolled within the Molecular and Clinical Markers for the Diagnosis and Management of type 1 VWD project. Complete response to desmopressin was defined as an increase of both ristocetin cofactor activity (VWF:RCo) and factor VIII coagulant activity (FVIII:C) to 50 IU/dL or higher and...
Topics
- Adolescent
- Adult
- Aged
- Blood Coagulation Tests
- Child
- Deamino Arginine Vasopressin
- Factor VIII
- Female
- Genotype