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LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation

14 Aug 2018

Abstract excerpt

De novo DNA methylation (DNAme) during mouse oogenesis occurs within transcribed regions enriched for H3K36me3. As many oocyte transcripts originate in long terminal repeats (LTRs), which are heterogeneous even between closely related mammals, we examined whether species-specific LTR-initiated transcription units (LITs) shape the oocyte methylome. Here we identify thousands of syntenic regions in mouse, rat, and...

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PMID: 30127397
DOI: 10.1038/s41467-018-05841-x

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