Article
Different Degrees of 5'-to-3' DAR Interactions Modulate Zika Virus Genome Cyclization and Host-Specific Replication.
Journal of virology - 14 Feb 2020
Li Xiao-Dan, Deng Cheng-Lin, Yuan Zhi-Ming, Ye Han-Qing, Zhang Bo
Abstract excerpt
Mosquito-borne flaviviruses, which include many important human pathogens, such as West Nile virus (WNV), dengue virus (DENV), and Zika virus (ZIKV), have caused numerous emerging epidemics in recent years. Details of the viral genome functions necessary for effective viral replication in mosquito and vertebrate hosts remain obscure. Here, using ZIKV as a model, we found that the conserved "downstream of AUG...
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