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Article

Viral RNA switch mediates the dynamic control of flavivirus replicase recruitment by genome cyclization

1 Oct 2016

Abstract excerpt

Viral replicase recruitment and long-range RNA interactions are essential for RNA virus replication, yet the mechanism of their interplay remains elusive. Flaviviruses include numerous important human pathogens, e.g., dengue virus (DENV) and Zika virus (ZIKV). Here, we revealed a highly conserved, conformation-tunable cis-acting element named 5′-UAR-flanking stem (UFS) in the flavivirus genomic 5′ terminus. We...

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PMID: 27692070
DOI: 10.7554/elife.17636

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