Article
Genetic analysis of West Nile virus containing a complete 3'CSI RNA deletion.
Virology - 20 Dec 2010
Zhang Bo, Dong Hongping, Ye Hanqing, Tilgner Mark, Shi Pei-Yong
Abstract excerpt
We report a genetic interplay among three pairs of long-distance RNA interactions that are involved in West Nile virus (WNV) genome cyclization and replication: 5'CS/3'CSI (conserved sequence), 5'UAR/3'UAR (upstream AUG region), and 5'DAR/3'DAR (downstream AUG region). Deletion of the complete 3'CSI element is lethal for WNV replication, but the replication of the 3'CSI deletion virus could be rescued by second...
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