Article
Functional analysis of dengue virus cyclization sequences located at the 5' and 3'UTRs.
Virology - 25 May 2008
Alvarez Diego E, Filomatori Claudia V, Gamarnik Andrea V
Abstract excerpt
Flavivirus RNA replication involves cyclization of the viral genome. A model for this process includes a promoter element at the 5' end of the genome and long-range RNA-RNA interactions. Two pairs of complementary sequences present at the ends of the viral RNA, known as 5'-3'CS and 5'-3'UAR, have been proposed to be involved in dengue virus genome cyclization. The requirement of 5'-3'CS complementarity for viral...
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