The influence of natural adaptation of the DCS-PK structure on the replication efficiency of Zika virus.

Abstract excerpt

Multiple studies have reported that different clades or strains of Zika virus (ZIKV) replicated with varied efficiency in cell culture. However, the molecular basis of these differences remains unclear. In this study, it was first shown that the downstream of the 5'-cyclization sequence pseudoknot (DCS-PK) is required for efficient viral RNA (vRNA) replication of ZIKV, similar to its function in dengue virus...

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• Adaptation, Physiological
• Chlorocebus aethiops
• Nucleic Acid Conformation
• Replicon
• Vero Cells