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Article

Selenium supplementation fails to correct the selenoprotein synthesis defect in subjects with SBP2 gene mutations.

Thyroid : official journal of the American Thyroid Association - 1 Mar 2009

Schomburg Lutz, Dumitrescu Alexandra M, Liao Xiao-Hui, Bin-Abbas Bassam, Hoeflich Johanna, Köhrle Josef, Refetoff Samuel

Abstract excerpt

BACKGROUND: Selenium (Se) is an essential trace element needed for the biosynthesis of selenoproteins. Selenocysteine incorporation sequence binding protein 2 (SBP2) represents a key trans-acting factor for the co-translational insertion of selenocysteine into selenoproteins. We recently described children with mutations in the SBP2 gene who displayed abnormal thyroid function tests and reduced selenoprotein...

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Identifiers

PMID: 19265499
DOI: 10.1089/thy.2008.0397
PMCID: PMC2858371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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