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Article

Novel biological and clinical aspects of thyroid hormone metabolism.

Endocrine development - 1 Jan 2007

Dumitrescu Alexandra M, Refetoff Samuel

Abstract excerpt

Intracellular metabolism of thyroid hormone (TH) and availability of the active hormone T3 is regulated by three selenoprotein iodothyronine deiodinases (Ds). D1 and D2 convert the precursor T4 into the active hormone, T3. D3 is the principal inactivator of T4 and T3 to their respective metabolites, rT3 and T2. While acquired changes in D activities are common, inherited defects in humans were not known....

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Identifiers

PMID: 17684394
DOI: 10.1159/000106824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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