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Article

Claudin‐4‐targeted therapy using <i>Clostridium perfringens</i> enterotoxin for prostate cancer

8 Jun 2011

Abstract excerpt

BACKGROUND: Clostridium perfringens enterotoxin (CPE) triggers lysis of epithelial cells through binding to tight-junction proteins claudin-3 (Cldn3) and Cldn4, which are over-expressed in prostate cancer. We investigated the potential of Cldn-targeted therapy using CPE. METHODS: We investigated the expression levels and subcellular localization of Cldn3 and Cldn4 in primary human prostate cancer tissues, human...

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PMID: 21656836
DOI: 10.1002/pros.21436

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