Article
Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in Caenorhabditis elegans.
PLoS genetics - 1 Dec 2019
Shomer Naomi, Kadhim Alexandre Zacharie, Grants Jennifer Margaret, Cheng Xuanjin, Alhusari Deema, Bhanshali Forum, Poon Amy Fong-Yuk, Lee Michelle Ying Ya, Muhuri Anik, Park Jung In, Shih James, Lee Dongyeop, Lee Seung-Jae V, Lynn Francis Christopher, Taubert Stefan
Abstract excerpt
Zinc is essential for cellular functions as it is a catalytic and structural component of many proteins. In contrast, cadmium is not required in biological systems and is toxic. Zinc and cadmium levels are closely monitored and regulated as their excess causes cell stress. To maintain homeostasis, organisms induce metal detoxification gene programs through stress responsive transcriptional regulatory complexes....
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