Article
The Nuclear Receptor HIZR-1 Uses Zinc as a Ligand to Mediate Homeostasis in Response to High Zinc.
PLoS biology - 1 Jan 2017
Warnhoff Kurt, Roh Hyun C, Kocsisova Zuzana, Tan Chieh-Hsiang, Morrison Andrew, Croswell Damari, Schneider Daniel L, Kornfeld Kerry
Abstract excerpt
Nuclear receptors were originally defined as endocrine sensors in humans, leading to the identification of the nuclear receptor superfamily. Despite intensive efforts, most nuclear receptors have no known ligand, suggesting new ligand classes remain to be discovered. Furthermore, nuclear receptors are encoded in the genomes of primitive organisms that lack endocrine signaling, suggesting the primordial function...
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