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Hemogenic endothelium during development and beyond

14 Mar 2012

Abstract excerpt

During embryonic development, multilineage HSCs/progenitor cells are derived from specialized endothelial cells, termed hemogenic endothelium, within the yolk sac, placenta, and aorta. Whether hemogenic endothelial cells contribute to blood cell development at other sites of definitive hematopoiesis, such as in the fetal liver and fetal bone marrow, is not known. Also unknown is whether such cells exist within...

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PMID: 22415753
DOI: 10.1182/blood-2011-12-353466

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