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Article

Bile acid receptor TGR5 is critically involved in preference for dietary lipids and obesity.

The Journal of nutritional biochemistry - 1 Feb 2020

Bensalem Adel, Murtaza Babar, Hichami Aziz, Khan Amira Sayed, Oulamara Hayet, Merlen Gregory, Berrichi Mustapha, Agli Abdel-Nacer, Tordjmann Thierry, Khan Naim Akhtar

Abstract excerpt

We investigated the implication of Takeda G protein-coupled receptor 5 (TGR5) in fat preference and fat sensing in taste bud cells (TBC) in C57BL/6 wild-type (WT) and TGR5 knock out (TGR5-/-) male mice maintained for 20 weeks on a high-fat diet (HFD). We also assessed the implication of TGR5 single nucleotide polymorphism (SNP) in young obese humans. The high-fat diet (HFD)-fed TGR5-/- mice were more obese,...

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Identifiers

PMID: 31812910
DOI: 10.1016/j.jnutbio.2019.108298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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