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Article

Single-nucleus chromatin accessibility reveals intratumoral epigenetic heterogeneity in IDH1 mutant gliomas.

Acta neuropathologica communications - 5 Dec 2019

Al-Ali Ruslan, Bauer Katharina, Park Jong-Whi, Al Abdulla Ruba, Fermi Valentina, von Deimling Andreas, Herold-Mende Christel, Mallm Jan-Philipp, Herrmann Carl, Wick Wolfgang, Turcan Şevin

Abstract excerpt

The presence of genome-wide DNA hypermethylation is a hallmark of lower grade gliomas (LGG) with isocitrate dehydrogenase (IDH) mutations. Further molecular classification of IDH mutant gliomas is defined by the presence (IDHmut-codel) or absence (IDHmut-noncodel) of hemizygous codeletion of chromosome arms 1p and 19q. Despite the DNA hypermethylation seen in bulk tumors, intra-tumoral heterogeneity at the...

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Identifiers

PMID: 31806013
DOI: 10.1186/s40478-019-0851-y
PMCID: PMC6896263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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