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Article

A complete overview of REEP1: old and new insights on its role in hereditary spastic paraplegia and neurodegeneration.

Reviews in the neurosciences - 26 May 2020

Guglielmi Alessio

Abstract excerpt

At the end of 19th century, Adolf von Strümpell and Sigmund Freud independently described the symptoms of a new pathology now known as hereditary spastic paraplegia (HSP). HSP is part of the group of genetic neurodegenerative diseases usually associated with slow progressive pyramidal syndrome, spasticity, weakness of the lower limbs, and distal-end degeneration of motor neuron long axons. Patients are typically...

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Identifiers

PMID: 31913854
DOI: 10.1515/revneuro-2019-0083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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