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Article

CGRRF1, a growth suppressor, regulates EGFR ubiquitination in breast cancer.

Breast cancer research : BCR - 4 Dec 2019

Lee Yu-Ju, Ho Shiuh-Rong, Graves Joshua D, Xiao Yang, Huang Shixia, Lin Weei-Chin

Abstract excerpt

BACKGROUND: CGRRF1 is a growth suppressor and consists of a transmembrane domain and a RING-finger domain. It functions as a RING domain E3 ubiquitin ligase involved in endoplasmic reticulum-associated degradation. The expression of CGRRF1 is decreased in cancer tissues; however, the role of CGRRF1 in breast cancer and the mechanism(s) of its growth suppressor function remain to be elucidated. METHODS: To...

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Source

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Identifiers

PMID: 31801577
DOI: 10.1186/s13058-019-1212-2
PMCID: PMC6894136

Genes

CGRRF1
EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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