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Article

The ubiquitin ligase LONRF2 inhibits glycolysis and malignant phenotypes in endometrial cancer through aldolase a degradation.

The Journal of biological chemistry - 1 Sept 2026

Shao Juan, Jiang Cui, Duan Yingchun, Chen Li, Gu Jiashi, Sun Huanmei, Xu Congjian

Abstract excerpt

The pathogenesis of endometrial cancer (EC) remains poorly understood. This study aimed to delineate the expression profile of LON peptidase N-terminal domain and ring finger 2 (LONRF2) in EC and to elucidate its mechanistic role in modulating the proliferative, metabolic, and invasive capacities of EC cells. LONRF2 expression was analyzed in EC tissues and cell lines. EC cells overexpressing LONRF2 were...

Read the complete abstract on PubMed

Topics

Female
Endometrial Neoplasms
Humans
Glycolysis
Animals
Phenotype
Fructose-Bisphosphate Aldolase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Ubiquitin-Protein Ligases

Mice

Proteolysis

Cell Proliferation

Cell Line, Tumor

Mice, Nude

Source

Open in PubMed Open full text

Identifiers

PMID: 42442502
DOI: 10.1016/j.jbc.2026.113325
PMCID: PMC13470188

Genes

LONRF2
ALDOA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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