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Article

Promoter polymorphisms of TOP2A and ERCC1 genes as predictive factors for chemotherapy in non-small cell lung cancer patients.

Cancer medicine - 1 Jan 2020

Grenda Anna, Błach Justyna, Szczyrek Michał, Krawczyk Paweł, Nicoś Marcin, Kuźnar Kamińska Barbara, Jakimiec Monika, Balicka Grażyna, Chmielewska Izabela, Batura-Gabryel Halina, Sawicki Marek, Milanowski Janusz

Abstract excerpt

BACKGROUND: Topoisomerase 2-alpha (TOP2A) is an enzyme that controls topologic changes in DNA during transcription and replication. ERCC1 is an enzyme that takes part in DNA repair processes. The purpose of this study was to assess the predictive role of particular single nucleotide polymorphisms (SNPs) in the promoter regions of TOP2A and ERCC1 genes in non-small cell lung cancer patients (NSCLC) treated with...

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Identifiers

PMID: 31797573
DOI: 10.1002/cam4.2743
PMCID: PMC6970032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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