Subendothelial stiffness alters endothelial cell traction force generation while exerting a minimal effect on the transcriptome

Abstract excerpt

Endothelial cells respond to changes in subendothelial stiffness by altering their migration and mechanics, but whether those responses are due to transcriptional reprogramming remains largely unknown. We measured traction force generation and also performed gene expression profiling for two endothelial cell types grown in monolayers on soft or stiff matrices: primary human umbilical vein endothelial cells...

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