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Article

Functional Polymorphism in the NFE2L2 Gene Associated With Tuberculosis Susceptibility.

Frontiers in immunology - 1 Jan 2021

Ji Guiyi, Zhang Miaomiao, Liu Qianqian, Wu Shouquan, Wang Yu, Chen Guo, Sandford Andrew J, He Jian-Qing

Abstract excerpt

Background: Nuclear transcription factor erythroid 2 p45-related factor 2 (Nrf2), encoded by NFE2L2, functions as a key transcription factor and regulates expression of antioxidant genes. Our study aimed to investigate the association of single nucleotide polymorphisms of NFE2L2 with tuberculosis (TB) and latent tuberculosis infection (LTBI) and the underlying causal mechanisms. Methods: 1950 unrelated Chinese...

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Identifiers

PMID: 34108963
DOI: 10.3389/fimmu.2021.660384
PMCID: PMC8181729

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