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Article

Comparative analysis of genetic toxicity of antiretroviral combinations in somatic cells of Drosophila melanogaster.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Mar 2013

Guimarães N N, Silva C J, de Andrade H H R, Dihl R R, Lehmann M, Cunha K S

Abstract excerpt

Nucleoside reverse-transcriptase inhibitor (NRTI) drugs are a major component of highly-active antiretroviral therapy (HAART). NRTI combinations have been demonstrated as producing a sustained reduction in plasma viremia with an increased CD4 count, thereby showing clear clinical benefits. Therefore, the secondary effects caused by the combination of two NRTIs, mainly those related to amplification of genotoxic...

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Identifiers

PMID: 23261680
DOI: 10.1016/j.fct.2012.12.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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