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Article

Phenotypic proteomic profiling identifies a landscape of targets for circadian clock-modulating compounds.

Life science alliance - 1 Dec 2019

Ray Sandipan, Lach Radoslaw, Heesom Kate J, Valekunja Utham K, Encheva Vesela, Snijders Ambrosius P, Reddy Akhilesh B

Abstract excerpt

Determining the exact targets and mechanisms of action of drug molecules that modulate circadian rhythms is critical to develop novel compounds to treat clock-related disorders. Here, we have used phenotypic proteomic profiling (PPP) to systematically determine molecular targets of four circadian period-lengthening compounds in human cells. We demonstrate that the compounds cause similar changes in...

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Identifiers

PMID: 31792063
DOI: 10.26508/lsa.201900603
PMCID: PMC6892409

Genes

CDK2
NGF
TNIK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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