Article
From structure to function for the characterization of ERAP1 active site in Behçet syndrome. A novel polymorphism associated with known gene variations.
Molecular immunology - 1 Jan 2020
Padula Maria Carmela, Leccese Pietro, Lascaro Nancy, Carbone Teresa, Limongi Antonina Rita, Radice Rosa Paola, Padula Angela Anna, D'Angelo Salvatore, Martelli Giuseppe
Abstract excerpt
INTRODUCTION: ERAP1 has been recently proposed as risk marker of Behçet syndrome (BS). Gene single nucleotide polymorphisms (SNPs) could affect the enzymatic activity and the conserved active site is pivotal for the aminopeptidase function. This study aims to characterize the ERAP1 active site in a cohort of BS patients vs healthy controls (HC) integrating genomics, transcriptomics and bioinformatics approach....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.