Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.

doi:10.1038/ng.2520

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Article

Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.

Nature genetics - 1 Feb 2013

Kirino Yohei, Bertsias George, Ishigatsubo Yoshiaki, Mizuki Nobuhisa, Tugal-Tutkun Ilknur, Seyahi Emire, Ozyazgan Yilmaz, Sacli F Sevgi, Erer Burak, Inoko Hidetoshi, Emrence Zeliha, Cakar Atilla, Abaci Neslihan, Ustek Duran, Satorius Colleen, Ueda Atsuhisa, Takeno Mitsuhiro, Kim Yoonhee, Wood Geryl M, Ombrello Michael J, Meguro Akira, Gül Ahmet, Remmers Elaine F, Kastner Daniel L

Abstract excerpt

Individuals with Behçet's disease suffer from episodic inflammation often affecting the orogenital mucosa, skin and eyes. To discover new susceptibility loci for Behçet's disease, we performed a genome-wide association study (GWAS) of 779,465 SNPs with imputed genotypes in 1,209 Turkish individuals with Behçet's disease and 1,278 controls. We identified new associations at CCR1, STAT4 and KLRC4. Additionally, two...

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Source

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Identifiers

PMID: 23291587
DOI: 10.1038/ng.2520
PMCID: PMC3810947

Genes

ERAP1
CCR1
STAT4
KLRC4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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