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Article

Successful target cell transduction of capsid-engineered rAAV vectors requires clathrin-dependent endocytosis.

Gene therapy - 1 Feb 2012

Uhrig S, Coutelle O, Wiehe T, Perabo L, Hallek M, Büning H

Abstract excerpt

Cell surface targeting of recombinant adeno-associated virus (rAAV) vectors is an attractive strategy to modify AAV's natural tropism. As modification of the capsid surface is likely to affect the mechanism of vector internalization and consequently the vector's intracellular fate, we investigate...

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Share to Capsid Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endocytosis

Share to Hep G2 Cells

Share to Heparan Sulfate Proteoglycans

Share to Transduction, Genetic

Share to Virus Internalization

Source

Identifiers

PMID: 21654820
DOI: 10.1038/gt.2011.78

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21654820-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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