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Article

The crystal structure of ESBL TLA-1 in complex with clavulanic acid reveals a second acylation site.

Biochemical and biophysical research communications - 5 Feb 2020

Cifuentes-Castro Víctor, Rodríguez-Almazán Claudia, Silva-Sánchez Jesús, Rudiño-Piñera Enrique

Abstract excerpt

β-lactamases are the main molecules responsible for giving bacterial resistance against β-lactam antibiotics. The study of β-lactamases has allowed the development of antibiotics capable of inhibiting these enzymes. In this context, extended spectrum β-lactamase (ESBL) TLA-1 has spread in Escherichia coli and Enterobacter cloacae clinical isolates during the last 30 years in Mexico. In this research, the 3D...

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PMID: 31780261
DOI: 10.1016/j.bbrc.2019.11.138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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