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Article

Homology modeling and virtual screening of inhibitors against TEM- and SHV-type-resistant mutants: A multilayer filtering approach.

Biotechnology and applied biochemistry - 1 Jan 2000

Baig Mohammad H, Balaramnavar Vishal M, Wadhwa Gulshan, Khan Asad U

Abstract excerpt

TEM and SHV are class-A-type β-lactamases commonly found in Escherichia coli and Klebsiella pneumoniae. Previous studies reported S130G and K234R mutations in SHVs to be 41- and 10-fold more resistant toward clavulanic acid than SHV-1, respectively, whereas TEM S130G and R244S also showed the same level of resistance. These selected mutants confer higher level of resistance against clavulanic acid. They also show...

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PMID: 25779642
DOI: 10.1002/bab.1370

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