Article
[Bacterial TEM-type serine beta-lactamases: structure and analysis of mutations].
Biomeditsinskaia khimiia - 1 Nov 2017
Grigorenko V G, Rubtsova M Yu, Uporov I V, Ishtubaev I V, Andreeva I P, Shcherbinin D S, Veselovsky A V, Egorov A M
Abstract excerpt
Beta-lactamases (EC 3.5.2.6) represent a superfamily containing more than 2,000 members: it includes genetically and functionally different bacterial enzymes capable to destroy the beta-lactam antibiotics. The most common are beta-lactamases of molecular class A with serine in the active center. Among them, TEM-type beta-lactamases are of particular interest from the viewpoint of studying the mechanisms of the...
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