Article
The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction.
Human genetics - 1 Nov 2006
Flanagan Jonathan M, Gerber Alexandra L, Cadet Jean Lud, Beutler Ernest, Sipe Jack C
Abstract excerpt
The human fatty acid amide hydrolase (FAAH) missense mutation c.385 C-->A, which results in conversion of a conserved proline residue to threonine (P129T), has been associated with street drug use and problem drug abuse. Although a link between the FAAH P129T variant and human drug abuse has been reported, the extent of risk and specific types of substance addiction vulnerability remain to be determined. Here, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.