Article
microRNA-605 rs2043556 polymorphisms affect clopidogrel therapy through modulation of CYP2B6 and P2RY12 in acute coronary syndrome patients.
Platelets - 2 Oct 2020
Zhou Wan-Lu, Mo Zhen-Zhen, Xiao Fei-Yan, Dai Wei, Wang Guo, Zhou Gan, Zhang Wei, Chen Bi-Lian
Abstract excerpt
Clopidogrel therapy reduces the occurrence of major vascular events in acute coronary syndrome (ACS) patients, but treatment efficacy is variable. The present study aims to determine the mechanisms that underlie associations between certain miRNA polymorphisms and clinical outcomes of clopidogrel therapy. Our study focused on 9 miRNA single nucleotide polymorphisms in addition to CYP2C19*2 and CYP2C19*3. We found...
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