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Article

Associations of CYP3A4, NR1I2, CYP2C19 and P2RY12 polymorphisms with clopidogrel resistance in Chinese patients with ischemic stroke.

Acta pharmacologica Sinica - 1 Jul 2016

Liu Rui, Zhou Zi-Yi, Chen Yi-Bei, Li Jia-Li, Yu Wei-Bang, Chen Xin-Meng, Zhao Min, Zhao Yuan-Qi, Cai Ye-Feng, Jin Jing, Huang Min

Abstract excerpt

AIM: There is a high incidence of the antiplatelet drug clopidogrel resistance (CR) in Asian populations. Because clopidogrel is a prodrug, polymorphisms of genes encoding the enzymes involved in its biotransformation may be the primary influential factors. The goal of this study was to investigate the associations of polymorphisms of CYP3A4, NR1I2, CYP2C19 and P2RY12 genes with CR in Chinese patients with...

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Identifiers

PMID: 27133299
DOI: 10.1038/aps.2016.41
PMCID: PMC4933760

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