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Article

Influence of genetic polymorphisms in P2Y12 receptor signaling pathway on antiplatelet response to clopidogrel in coronary heart disease.

BMC cardiovascular disorders - 30 Dec 2022

Zhang Yan-Jiao, Li Dong-Jie, Li Zhong-Yi, Hu Xiao-Lei, Li He, Ma Qi-Lin, Chen Xiao-Ping

Abstract excerpt

BACKGROUNDS: Remarkable interindividual variability in clopidogrel response is observed, genetic polymorphisms in P2RY12 and its signal pathway is supposed to affect clopidogrel response in CHD patients. METHODS: 539 CHD patients treated with clopidogrel were recruited. The platelet reaction index (PRI) indicated by VASP-P level were detected in 12-24 h after clopidogrel loading dose or within 5-7 days after...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C19

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Share to Platelet Aggregation Inhibitors

Share to Polymorphism, Single Nucleotide

Share to Purinergic P2Y Receptor Antagonists

Share to Receptors, Purinergic P2Y12

Source

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Identifiers

PMID: 36581799
DOI: 10.1186/s12872-022-02988-w
PMCID: PMC9801627

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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