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Article

Mechanistic Signatures of Human Papillomavirus Insertions in Anal Squamous Cell Carcinomas

22 Nov 2019

Abstract excerpt

The role of human papillomavirus (HPV) in anal squamous cell carcinoma (ASCC) carcinogenesis has been clearly established, involving the expression of viral oncoproteins and optional viral DNA integration into the host genome. In this article, we describe the various mechanisms and sites of HPV DNA insertion and assess their prognostic and predictive value in a large series of patients with HPV-positive ASCC with...

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PMID: 31766658
DOI: 10.3390/cancers11121846

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