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Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge

22 Nov 2019

Abstract excerpt

We previously generated a panel of human monoclonal antibodies (mAbs) against Zika virus (ZIKV) and identified one, ZIKV-116, that shares germline usage with mAbs identified in multiple donors. Here we show that ZIKV-116 interferes with ZIKV infection at a post-cellular attachment step by blocking viral fusion with host membranes. ZIKV-116 recognizes the lateral ridge of envelope protein domain III, with one...

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PMID: 31757867
DOI: 10.1084/jem.20191792

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