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Article

The MAPK Hog1 mediates the response to amphotericin B in Candida albicans.

Fungal genetics and biology : FG & B - 1 Mar 2020

Guirao-Abad José Pedro, Sánchez-Fresneda Ruth, Román Elvira, Pla Jesús, Argüelles Juan Carlos, Alonso-Monge Rebeca

Abstract excerpt

The HOG MAP kinase pathway plays a crucial role in the response to different stresses in the opportunistic pathogen Candida albicans. The polyene amphotericin B (AMB) has been reported to trigger oxidative stress in several pathogenic fungi, including C. albicans. In the present work, we have analyzed the role of the MAPK Hog1 in sensing and survival to AMB treatment. Mutants lacking Hog1 are more susceptible to...

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PMID: 31756382
DOI: 10.1016/j.fgb.2019.103302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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